First Detection of Influenza D Virus Infection in Cattle and Pigs in the Republic of Korea

Influenza D virus (IDV) belongs to the Orthomyxoviridae family, which also include influenza A, B and C genera. IDV was first detected isolated in 2011 United States from pigs with respiratory illness. circulates mammals, including pigs, cattle, camelids, horses small ruminants. Despite broad host range, cattle are thought be natural reservoir of IDV. This plays a role as causative agent bovine disease complex (BRDC). has been identified North America, Europe, Asia Africa. However, there no information on presence Republic Korea (ROK). In this study, we investigated viral RNA seroprevalence among ROK 2022. Viral surveyed by collection testing 999 2391 pig nasal swabs lung tissues using real-time RT-PCR assay. 742 1627 sera hemagglutination inhibition (HI) The positive rate 1.4% but pigs. Phylogenetic analysis hemagglutinin-esterase-fusion (HEF) gene further conducted for selection samples. All sequences belonged D/Yamagata/2019 lineage. seropositivity rates were 54.7% geometric mean antibody titer (GMT) 68.3 48.5 is report detection antibodies ROK.